| 02.12.1905 | Leyton Orient | 4 | - | 0 | W | 12.000 | LgDiv2 | H | Bank Street | Jack Peddie x2, Jack Picken x2 | |||||
| 07.04.1906 | Leyton Orient | 1 | - | 0 | W | 8.000 | LgDiv2 | U | Millfields Road | George Wall | |||||
| 04.11.1922 | Leyton Orient | 0 | - | 0 | D | 16.500 | LgDiv2 | H | Old Trafford | ||||||
| 11.11.1922 | Leyton Orient | 1 | - | 1 | D | 11.000 | LgDiv2 | U | Millfields Road | Ernest Goldthorpe | |||||
| 18.04.1924 | Leyton Orient | 0 | - | 1 | L | 18.000 | LgDiv2 | U | Millfields Road | ||||||
| 21.04.1924 | Leyton Orient | 2 | - | 2 | D | 11.000 | LgDiv2 | H | Old Trafford | Sydney Evans x2 | |||||
| 04.10.1924 | Leyton Orient | 1 | - | 0 | W | 15.000 | LgDiv2 | U | Millfields Road | Arthur Lochhead | |||||
| 07.02.1925 | Leyton Orient | 4 | - | 2 | W | 18.250 | LgDiv2 | H | Old Trafford | Fredrick Kennedy x2, Francis McPherson, Albert Pape | |||||
| 08.09.1962 | Orient | 0 | - | 1 | L | 24.901 | LgDiv1 | U | Brisbane Road | ||||||
| 18.05.1963 | Orient | 3 | - | 1 | W | 32.759 | LgDiv1 | H | Old Trafford | Stan Charlton 52' (o.g.), Denis Law 81', Bobby Charlton 85' | |||||
| 17.08.1974 | Orient | 2 | - | 0 | W | 17.772 | LgDiv2 | U | Brisbane Road | Willie Morgan, Stewart Houston | |||||
| 14.12.1974 | Orient | 0 | - | 0 | D | 41.200 | LgDiv2 | H | Old Trafford |