| 14.12.2005 | Wigan Athletic | 4 | - | 0 | W | 67.793 | LgPL | H | Old Trafford | Rio Ferdinand 30', Wayne Rooney 35', 55', Ruud van Nistlerooy 70' (pen) | |||||
| 26.02.2006 | Wigan Athletic | 4 | - | 0 | W | 66.866 | LCup | F | N | Mellenium Stadium | Wayne Rooney 33', 61', Louis Saha 55', Cristiano Ronaldo 59' | ||||
| 06.03.2006 | Wigan Athletic | 2 | - | 1 | W | 23.574 | LgPL | U | JJB Stadium | Cristiano Ronaldo 74', Pascal Chimbonda 90' (o.g.) | |||||
| 14.10.2006 | Wigan Athletic | 3 | - | 1 | W | 20.631 | LgPL | U | JJB Stadium | Nemanja Vidic 62', Louis Saha 66', Ole Gunnar Solskjaer 90' | |||||
| 26.12.2006 | Wigan Athletic | 3 | - | 1 | W | 76.018 | LgPL | H | Old Trafford | Cristiano Ronaldo 47', 51', Ole Gunnar Solskjaer 59' | |||||
| 06.10.2007 | Wigan Athletic | 4 | - | 0 | W | 75.300 | LgPL | H | Old Trafford | Carlos Tevez 54', Cristiano Ronaldo 59', 76', Wayne Rooney 82' | |||||
| 11.05.2008 | Wigan Athletic | 2 | - | 0 | W | 24.133 | LgPL | U | JJB Stadium | Cristiano Ronaldo 33' (pen), Ryan Giggs 80' | |||||
| 14.01.2009 | Wigan Athletic | 1 | - | 0 | W | 73.917 | LgPL | H | Old Trafford | Wayne Rooney 1' | |||||
| 13.05.2009 | Wigan Athletic | 2 | - | 1 | W | 21.286 | LgPL | U | JJB Stadium | Carlos Tevez 61', Michael Carrick 86' | |||||
| 22.08.2009 | Wigan Athletic | 5 | - | 0 | W | 18.164 | LgPL | U | DW Stadium | Wayne Rooney 56', 65', Dimitar Berbatov 58', Michael Owen 86', Nani 90' | |||||
| 30.12.2009 | Wigan Athletic | 5 | - | 0 | W | 74.560 | LgPL | H | Old Trafford | Wayne Rooney 28', Michael Carrick 32', Rafael da Silva 45', Dimitar Berbatov 50', Antonio Valencia 75' | |||||
| 20.11.2010 | Wigan Athletic | 2 | - | 0 | W | 74.181 | LgPL | H | Old Trafford | Patrice Evra 45'+1, Javier Hernandez 77' | |||||
| 26.02.2011 | Wigan Athletic | 4 | - | 0 | W | 18.140 | LgPL | U | DW Stadium | Javier Hernandez 17', 74', Wayne Rooney 84', Fabio da Silva 87' | |||||
| 26.12.2011 | Wigan Athletic | 5 | - | 0 | W | 75.183 | LgPL | H | Old Trafford | Ji-Sung Park 8', Dimitar Berbatov 41', 58', 78' (pen), Antonio Valencia 75' | |||||
| 11.04.2012 | Wigan Athletic | 0 | - | 1 | L | 18.115 | LgPL | U | DW Stadium | ||||||
| 15.09.2012 | Wigan Athletic | 4 | - | 0 | W | 75.142 | LgPL | H | Old Trafford | Paul Scholes 51', Javier Hernandez 63', Alexander Buttner 66', Nick Powell 82' | |||||
| 01.01.2013 | Wigan Athletic | 4 | - | 0 | W | 20.342 | LgPL | U | DW Stadium | Javier Hernandez 35', 63', Robin van Persie 43', 88' | |||||
| 11.08.2013 | Wigan Athletic | 2 | - | 0 | W | 80.235 | CS | F | N | Wembley | Robin van Persie 6', 59' | ||||
| 28.01.2017 | Wigan Athletic | 4 | - | 0 | W | 75.229 | FACup | R4 | H | Old Trafford | Marouane Fellaini 44', Chris Smalling 57', Henrikh Mkhitaryan 74', Bastian Schweinsteiger 81' |