| 16.01.1909 | Brighton & Hove Albion | 1 | - | 0 | W | 8.300 | FACup | R1 | H | Bank Street | Harold Halse | ||||
| 06.10.1979 | Brighton & Hove Albion | 2 | - | 0 | W | 52.641 | LgDiv1 | H | Old Trafford | Steve Coppell 26', Lou Macari 58' | |||||
| 15.03.1980 | Brighton & Hove Albion | 0 | - | 0 | D | 29.621 | LgDiv1 | U | Goldstone Ground | ||||||
| 22.11.1980 | Brighton & Hove Albion | 4 | - | 1 | W | 23.293 | LgDiv1 | U | Goldstone Ground | Joe Jordan x2, Sammy McIlroy, Mike Duxbury | |||||
| 03.01.1981 | Brighton & Hove Albion | 2 | - | 2 | D | 42.199 | FACup | R3 | H | Old Trafford | Mike Duxbury 7 ', Mickey Thomas 74' | ||||
| 07.01.1981 | Brighton & Hove Albion | 2 | - | 0 | W | 26.915 | FACup | R3rp | U | Goldstone Ground | Jimmy Nicholl 33', Garry Birtles 8 ' | ||||
| 10.01.1981 | Brighton & Hove Albion | 2 | - | 1 | W | 42.208 | LgDiv1 | H | Old Trafford | Gordon McQueen 34', Lou Macari 63' | |||||
| 28.11.1981 | Brighton & Hove Albion | 2 | - | 0 | W | 41.911 | LgDiv1 | H | Old Trafford | Garry Birtles 38', Frank Stapleton 68' | |||||
| 24.04.1982 | Brighton & Hove Albion | 1 | - | 0 | W | 20.750 | LgDiv1 | U | Goldstone Ground | Ray Wilkins 87' | |||||
| 06.11.1982 | Brighton & Hove Albion | 0 | - | 1 | L | 18.379 | LgDiv1 | U | Goldstone Ground | ||||||
| 19.03.1983 | Brighton & Hove Albion | 1 | - | 1 | D | 36.264 | LgDiv1 | H | Old Trafford | Arthur Albiston 56' | |||||
| 21.05.1983 | Brighton & Hove Albion | 2 | - | 2 | D | 100.000 | FACup | F | aet | N | Wembley | Frank Stapleton 55', Ray Wilkins 72' | |||
| 26.05.1983 | Brighton & Hove Albion | 4 | - | 0 | W | 92.000 | FACup | Frp | N | Wembley | Bryan Robson 25', 44', Norman Whiteside 29', Arnold Muhren 63' (pen) | ||||
| 23.09.1992 | Brighton & Hove Albion | 1 | - | 1 | D | 16.649 | LCup | R2-1 | U | Goldstone Ground | Danny Wallace 36' | ||||
| 07.10.1992 | Brighton & Hove Albion | 1 | - | 0 | W | 25.405 | LCup | R2-2 | H | Old Trafford | Mark Hughes 14' | ||||
| 23.01.1993 | Brighton & Hove Albion | 1 | - | 0 | W | 33.610 | FACup | R4 | H | Old Trafford | Ryan Giggs 75' | ||||
| 25.11.2017 | Brighton & Hove Albion | 1 | - | 0 | W | 75.018 | LgPL | H | Old Trafford | Lewis Dunk 66' o.g. | |||||
| 17.03.2018 | Brighton & Hove Albion | 2 | - | 0 | W | 74.241 | FACup | R6 | H | Old Trafford | Romelu Lukaku 37', Nemanja Matic 83' | ||||
| 04.05.2018 | Brighton & Hove Albion | 0 | - | 1 | L | 30.611 | LgPL | U | Falmer Stadium | ||||||
| 19.08.2018 | Brighton & Hove Albion | 2 | - | 3 | L | 30.592 | LgPL | U | AMEX Stadium | Romelu Lukaku 34', Paul Pogba 90+4' (pen) | |||||
| 19.01.2019 | Brighton & Hove Albion | 2 | - | 1 | W | 74.653 | LgPL | H | Old Trafford | Paul Pogba 27' (pen), Marcus Rashford 42' |